Data from a Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) Study (1994-2002) indicated that antioxidant supplements were compared with a “greater healthy aging probability” among men, though not women. The double-blind, placebo-controlled SU.VI.MAX examine concerned prolonged tenure supplementation with vitamin C (120 mg), beta-carotene (6 mg), vitamin E (30 mg), selenium (100 ug), and zinc (20 mg).
“To a best of a knowledge, a examine is a initial to examine a attribute between antioxidant supplements and a multidimensional magnitude of healthy aging,” wrote a researchers, led by Karen Assmann from a Université Paris 13 in France.
“Our stratified analyses prove that, while an altogether profitable organisation of a supplementation with total antioxidant vitamins and minerals during assuage doses might not exist, specific subpopulations could advantage from antioxidant treatment. Yet, a branch analyses were of exploratory inlet and so have to be interpreted with caution. To determine a findings, serve randomized tranquil trials targeting populations during risk with a low baseline antioxidant standing would be needed. According to a data, organisation might be such an ‘at risk’ group.”
Oxidative highlight and aging
While oxidative highlight has been a concentration for a underlying biological mechanisms of aging and declines in health as we age, involvement trials regulating dietary supplements have mostly yielded opposing results.
The medical village and a mainstream media are mostly discerning to bring a argumentative meta-analyses by Bjelakovic et al. in the Journal of a American Medical Association (2007, Vol. 297, pp. 842-857) that resolved that vitamins A and E, and beta-carotene might boost mankind risk by adult to 16%.
However, that information was re-analyzed by a group of internationally eminent antioxidant scientists in 2010 that arrived during a opposite set of conclusions. This re-analysis, published in Nutrients
, found that 36% of a trials showed a certain outcome or that a antioxidant supplements were beneficial, 60% had a nothing outcome, while usually 4% found disastrous outcome.
There are also several meta-analyses of RCTs that contrariety with a work finished by Bjelakovic et al., that found no outcome on all-cause mankind for vitamin E supplements, including Berry et al (Clin Trials 2009, Vol. 6, pp. 28-41), Abner et al, (Curr Aging Sci 2011, Vol. 4, pp. 158-170), Curtis et al, (Cardiovasc Drugs Ther, 2014, Vol. 28, pp. 563-573), and Jiang et al (J Nutr Sci Vitaminol, 2014, Vol. 60, pp. 194-205).
It should also be remarkable that a 10-year PHS II RCT did not find any inauspicious outcomes for vitamin E (Wang et al., Am J Clin Nutr 2014, Vol. 100, pp. 915-23).
On a certain side, information from a European Prospective Investigation into Cancer and Nutrition (EPIC) examine published in 2012 also indicated that users of antioxidant vitamin supplements might be compared with a 48% rebate in a risk of cancer mankind and a 42% rebate in a risk of ‘all-cause mortality’ over 11 years of examine (European Journal of Nutrition
, Vol. 51, pp 407-413).
New data
Data from a SU.VI.MAX examine adds to a physique of novel around this subject, anticipating that, for a whole examine race of 3,966 participants with a meant age of 65.3, no poignant advantages were observed.
No poignant advantages were celebrated for women, either, conspicuous Assmann and her co-workers.
For men, however, antioxidant supplementation was compared with a aloft luck of healthy aging, they said.
Other subgroups also exhibited profitable effects from a supplements: In organisation and women with low vitamin C levels during a start of a study; in organisation with low zinc levels during a start of a study; and in organisation with low fruit and unfeeling intakes during a start of a examine (fewer than 5 portions per day).
“The outcome of supplementation seemed to be stronger among women with low vitamin C concentrations than among organisation with low serum vitamin C,” they wrote. “Yet, as usually few women had vitamin C concentrations next a 25th percentile, statistical energy was low, and no poignant formula were observed. It is probable that a sex specificity of a commentary is partly explained by sex differences in a superiority of low baseline vitamin C concentrations in a sample; that is, if as many women as organisation in a representation would have had low vitamin C concentrations during baseline, there might have been a some-more conspicuous altogether outcome of supplementation among women. However, there might be additional underlying factors.”
“Altogether, a formula support a significance of a well-balanced intake of antioxidant nutrients during nutritive doses (as can be granted by a diversified and adequate fruit and unfeeling intake) for preserving altogether health in a march of aging.”
Source: American Journal of Epidemiology
Published online forward of print, doi: 10.1093/aje/kwv105
“Healthy Aging 5 Years After a Period of Daily Supplementation With Antioxidant Nutrients: A Post Hoc Analysis of a French Randomized Trial SU.VI.MAX”
Authors: K.E. Assmann, V.A. Andreeva, C. Jeandel, S. Hercberg, P. Galan, E. Kesse-Guyot
‘An adequate supply of antioxidant nutrients may have a beneficial role for healthy aging’, says study
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